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KMID : 0371019880210020295
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Journal of Preventive Medicine and Public Health
1988 Volume.21 No. 2 p.295 ~ p.306
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Dose-Response Relationship between Catalase and Superoxide Dismutase Activity in Testes of Acutely Intoxicated Rats by Cadmium
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Abstract
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Dose-response relationship among blood cadmium concentrations, catalase and superoxide dismutase activities were studied with acutely intoxicated rats by cadmium. The Sprague-Dawley male rats to which single dose of 1^-32 mg/kg CdC12 were administered into peritoneal cavity were sacrificed by decapitation at 3~-36 hours after the administration.
Cadmium concentrations in blood increased significantly with dose of CdC12 administered and reached peak level at 3 hours later. Catalase activities in rats´ testes were not correlated with esposure time elapsed after the administration in rats to which 1--2 mg/kg of CdC12 were administered, but they showed linear relationship with time in groups to which 432 mg/kg of CdC12 were administered. Cu, Zn-SOD activities in testes of acutely intoxicated rats by cadmium were not altered either by dosage or by time elapsed after the administration. Mn-SOD activities in the testes were also not influenced by dosage of 1^-2 mg/kg CdC12, but remarkably inactivated by dosage of 4^-32 mg/kg CdC12 with time elapsed after the administration. Neither catalase, Cu, Zn-SOD nor Mn-SOD activities of testes were correlated with blood cadmium concentrations in acutely intoxicated rats by cadmium.
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